How stress and nicotine affect alcohol consumption in adolescents
Adolescent Exposure to Stress or Nicotine Increases Rodent Alcohol Self-Administration
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10671050
This study looks at how stress and nicotine during teenage years might lead to drinking more alcohol later on, using young rats to understand how these factors affect the brain, with hopes of finding ways to help prevent alcohol problems in young people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10671050 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to stress and nicotine during adolescence influences alcohol consumption behaviors. By using rodent models, the study examines the biological mechanisms that link these factors to increased alcohol self-administration. The researchers aim to understand how stress and nicotine alter brain function, particularly focusing on the role of glucocorticoid receptors and GABAergic circuitry. The findings could provide insights into preventing alcohol use disorders in young people.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12 to 20 who may be exposed to stress or nicotine.
Not a fit: Patients who are not adolescents or who do not have exposure to stress or nicotine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for alcohol use disorders in adolescents.
How similar studies have performed: Previous research has shown that stress and nicotine can influence alcohol consumption, but this study aims to explore these interactions in a more detailed and biologically relevant context.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANI, JOHN A. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: DANI, JOHN A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.