How stress and certain medications affect the immune response in ovarian tumors
Official title: The role of biobehavioral factors and anti-inflammatory medications on the ovarian tumor immune response
Funded at Oregon Health & Science University · NIH-10931649 · Data updated 2026-11-12
This study is looking at how long-term stress affects the immune system in women with ovarian cancer, especially how it might help tumors grow, and it will also explore whether medications like aspirin and beta-blockers can help reduce these stress-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $650,127 |
| NIH project number | 5R01CA276224-03 |
| Project ID | NIH-10931649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ovarian tumors who have experienced chronic social stress or distress.
✕Less likely to help
Patients with early-stage ovarian tumors who have not experienced significant social stress may not benefit from this research.
What this research studies
This research investigates how chronic social stress influences the immune response in ovarian tumors, particularly focusing on the role of specific immune cells that may promote tumor growth. It aims to understand how stress-related factors lead to inflammation and the recruitment of immunosuppressive cells in ovarian cancer. The study will analyze data from diverse populations and examine tumor tissue to identify immune markers, while also exploring the potential of medications like aspirin and beta-blockers to mitigate these effects.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance the immune response against ovarian tumors, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the impact of stress on cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Tworoger, Shelley S — Oregon Health & Science University
- Study coordinator: Tworoger, Shelley S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.