How stress affects sleep patterns and quality

Neural basis underlying the impact of stress on sleep

['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11058766

This study is looking at how stress affects sleep and thinking by using animal models to see how stress can disrupt sleep patterns, and it aims to help us understand the links between stress, sleep quality, and mental health.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF PENNSYLVANIA (nih funded)
Locations1 site (PHILADELPHIA, UNITED STATES)
Trial IDNIH-11058766 on ClinicalTrials.gov

What this research studies

This research investigates the relationship between stress and sleep quality, focusing on how stress leads to fragmented sleep and cognitive impairment. By studying animal models, the researchers aim to identify the brain circuits involved in regulating sleep and how stress disrupts these processes. The study will explore the mechanisms behind changes in sleep architecture, particularly the impact of stress on non-rapid eye movement and rapid eye movement sleep. Understanding these connections could provide insights into the effects of stress on mental health and sleep disorders.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals experiencing high levels of stress, insomnia, or cognitive difficulties.

Not a fit: Patients who do not experience stress-related sleep issues or cognitive impairments may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatments for sleep disorders and cognitive impairments associated with stress.

How similar studies have performed: Previous research has shown promising results in understanding the effects of stress on sleep, indicating that this approach has potential for significant findings.

Where this research is happening

PHILADELPHIA, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.