NIH-funded research R01 grant

How stress affects sleep patterns and quality

Official title: Neural basis underlying the impact of stress on sleep

Funded at University of Pennsylvania · NIH-11058766 · Data updated 2026-11-12

This study is looking at how stress affects sleep and thinking by using animal models to see how stress can disrupt sleep patterns, and it aims to help us understand the links between stress, sleep quality, and mental health.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania
NIH-funded
Lab location1 site (Philadelphia, United States)
Project startSeptember 18, 2024
Project endJuly 31, 2029
Funding year2024
Award (this year)$588,018
NIH project number1R01MH136491-01A1
Project IDNIH-11058766 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals experiencing high levels of stress, insomnia, or cognitive difficulties.

Less likely to help

Patients who do not experience stress-related sleep issues or cognitive impairments may not benefit from this research.

What this research studies

This research investigates the relationship between stress and sleep quality, focusing on how stress leads to fragmented sleep and cognitive impairment. By studying animal models, the researchers aim to identify the brain circuits involved in regulating sleep and how stress disrupts these processes. The study will explore the mechanisms behind changes in sleep architecture, particularly the impact of stress on non-rapid eye movement and rapid eye movement sleep. Understanding these connections could provide insights into the effects of stress on mental health and sleep disorders.

Why it matters

Potential benefit: If successful, this research could lead to improved treatments for sleep disorders and cognitive impairments associated with stress.

How similar studies have gone: Previous research has shown promising results in understanding the effects of stress on sleep, indicating that this approach has potential for significant findings.

Where this research is happening

  • University of Pennsylvania
    Philadelphia, United States
    Active

Researchers

  • Principal investigator: Chung, Shinjae — University of Pennsylvania
  • Study coordinator: Chung, Shinjae

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.