How stress affects regenerative treatments for urinary issues in monkeys
Psychosocial Stress Effects on Regenerative Medicine Therapies for Lower Urinary Tract Disorders in Nonhuman Primates
This study looks at how stress affects the success of treatments for urinary incontinence in female monkeys, especially those that are less dominant, to help us understand how stress might impact healing and improve therapies for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10923790 on NIH RePORTER |
What this research studies
This research investigates the impact of psychosocial stress on the effectiveness of regenerative medicine therapies for urinary incontinence, specifically in nonhuman primates. By examining socially subordinate female monkeys, the study aims to understand how stress influences their response to cell therapy compared to dominant monkeys. The researchers will assess various biological responses, including nervous system activation and hormonal changes, to identify pathways that may hinder regeneration in the urinary sphincter. This interdisciplinary approach combines insights from behavioral sciences, urology, and molecular pathology to address a significant knowledge gap in urinary health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing urinary incontinence, particularly those who may be affected by psychosocial stressors.
Not a fit: Patients without urinary incontinence or those not experiencing psychosocial stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved regenerative therapies for urinary incontinence by considering the effects of psychosocial factors.
How similar studies have performed: While this specific approach is novel, previous research has indicated that psychosocial factors can influence medical treatment outcomes.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Shively, Carol a. — Wake Forest University Health Sciences
- Study coordinator: Shively, Carol a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.