How stress affects inflammation and heart disease risk
Neural and Molecular Mechanisms Underlying Stress-Induced Inflammatory Responses
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11077220
This study is looking at how stress can cause inflammation in the body, which might lead to heart problems, and it’s for anyone interested in understanding how managing stress could help protect their heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11077220 on ClinicalTrials.gov |
What this research studies
This research investigates how psychological stress can lead to inflammation, which is a key factor in the development of cardiovascular disease (CVD). By using advanced imaging techniques like fMRI, the study aims to identify specific brain responses to stress and how these responses correlate with inflammatory markers in the body. Additionally, the research will explore the effects of blocking certain stress-related signaling pathways using pharmacological agents. This approach could help in understanding the biological mechanisms linking stress to heart disease and identifying potential intervention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing high levels of psychological stress who may be at risk for cardiovascular disease.
Not a fit: Patients who do not experience significant stress or have pre-existing severe cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease by targeting stress-induced inflammation.
How similar studies have performed: Previous research has shown promising results in understanding the link between stress and inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSCATELL, KEELY ANN — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: MUSCATELL, KEELY ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.