How stress affects energy balance in the body
Linking stress-associated brain and adipose functions
This study looks at how short-term stress affects energy use in the body, especially how the brain controls this process, and it’s designed for anyone interested in understanding how stress might impact appetite and energy levels, particularly in people dealing with stress-related issues like PTSD.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10900638 on NIH RePORTER |
What this research studies
This research investigates the effects of acute stress on energy metabolism, focusing on how the brain regulates these processes through specific receptors. It examines the role of the locus coeruleus, a brain region involved in stress responses, and its connection to brown adipose tissue, which is important for energy expenditure. The study uses a behavioral model in mice to explore how these mechanisms differ between sexes, particularly in relation to stress-related disorders like PTSD. By understanding these interactions, the research aims to uncover new insights into how stress influences appetite and energy balance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing stress-related disorders, particularly those with PTSD or obesity.
Not a fit: Patients who do not experience stress-related disorders or metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for stress-related disorders and obesity by targeting specific brain mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between stress and metabolism, but this specific approach is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Rajbhandari, Abha K — Icahn School of Medicine at Mount Sinai
- Study coordinator: Rajbhandari, Abha K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.