How stress affects DNA and brain function
Official title: The impact of stress-induced DNA breaks on chromatin structure, gene activity, and neuron function
Funded at University of Cincinnati · NIH-11006286 · Data updated 2026-11-12
This study looks at how long-term stress can change the DNA and structure of brain cells that affect our thoughts and behaviors, aiming to help people with conditions like PTSD and depression by finding new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 5, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $670,758 |
| NIH project number | 5R01MH130399-03 |
| Project ID | NIH-11006286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing symptoms of stress-related psychiatric disorders, such as PTSD or major depressive disorder.
✕Less likely to help
Patients who do not have stress-related psychiatric disorders may not benefit from this research.
What this research studies
This research investigates how chronic stress leads to changes in DNA and neuron structure in key brain areas that control behavior and cognition. By studying the effects of stress on DNA breaks in neurons, the research aims to uncover the molecular mechanisms behind stress-related psychiatric disorders like PTSD and major depressive disorder. The approach includes using animal models to observe the impact of stress on gene activity and neuron connectivity, with potential interventions being tested to mitigate these effects. This could help in understanding how stress influences mental health and developing new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for stress-related psychiatric disorders by targeting the underlying molecular changes in the brain.
How similar studies have gone: Previous research has shown that understanding the molecular effects of stress on the brain can lead to significant advancements in treatment approaches, indicating a promising avenue for this study.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Wohleb, Eric S — University of Cincinnati
- Study coordinator: Wohleb, Eric S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.