How stress affects cognitive decline in people at risk for Alzheimer's disease
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
This study is looking at how stress affects thinking and memory in people who might be at risk for Alzheimer's, and it aims to find ways to help those with mild cognitive issues by seeing how their bodies respond to stress.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11021032 on NIH RePORTER |
What this research studies
This research investigates how the body's response to stress may influence cognitive decline in individuals at risk for Alzheimer's disease. By examining the endocrine stress response and its effects on cognition, the study aims to identify specific predictors that could help target interventions for those with mild cognitive impairment. Participants will undergo a stress-inducing test, and their cognitive performance will be monitored over time to understand the relationship between stress and cognitive decline. The goal is to bridge the gap between laboratory findings and clinical applications for better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with mild cognitive impairment who are at risk for developing Alzheimer's disease.
Not a fit: Patients who do not have mild cognitive impairment or are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying cognitive decline in individuals at risk for Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding the link between stress and cognitive decline, making this approach both relevant and potentially impactful.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Munro, Cynthia Ann — Johns Hopkins University
- Study coordinator: Munro, Cynthia Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.