How stress affects brain signaling related to anxiety and emotional behavior
Stress-induced impairments in endogenous neurosteroid signaling in the BLA negatively impacts network and behavioral states
['FUNDING_R01'] · TUFTS UNIVERSITY BOSTON · NIH-10866547
This study is looking at how stress affects certain brain chemicals that help with emotions, and it hopes to find ways to boost these chemicals to improve mood and help people dealing with anxiety and similar issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10866547 on ClinicalTrials.gov |
What this research studies
This research investigates how stress impacts the signaling of neurosteroids in the brain, particularly in the basolateral amygdala (BLA), which is crucial for emotional processing. By using a chronic unpredictable stress model, the study aims to understand how these changes in brain signaling can lead to shifts between healthy and unhealthy emotional states. The research also explores the potential of enhancing neurosteroid production to improve brain function and emotional well-being. Patients may benefit from insights that could lead to new treatments for anxiety and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing anxiety disorders or related affective conditions.
Not a fit: Patients with non-affective disorders or those not experiencing anxiety may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing anxiety and improving emotional health.
How similar studies have performed: Previous research has shown promising results in using neurosteroids for treating anxiety, indicating that this approach has potential based on earlier successes.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAGUIRE, JAMIE LYNN — TUFTS UNIVERSITY BOSTON
- Study coordinator: MAGUIRE, JAMIE LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Affective Disorders