How stress affects brain neurons that control hormone release
Stress Plasticity of CRH Neurons
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11134180
This study is looking at how certain brain cells react to different kinds of stress and how these reactions might differ between men and women, with the goal of understanding stress better and finding new ways to help people with stress-related mental health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11134180 on ClinicalTrials.gov |
What this research studies
This research investigates how corticotropin-releasing hormone (CRH) neurons in the brain respond to different types of stress, including physical and psychological stress. It aims to understand the differences in how males and females react to stress and how these reactions can lead to mental health disorders. By studying the connections and circuits of these neurons, the research seeks to uncover the mechanisms that regulate stress responses and hormone release, which could have implications for treating stress-related conditions. The approach includes examining brain activity in response to stressors and how this affects behavior and hormone levels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing stress-related mental health issues, particularly those who may have different responses based on their sex.
Not a fit: Patients who do not experience stress-related disorders or who have other unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for stress-related mental health disorders by targeting specific brain circuits.
How similar studies have performed: Previous studies have shown promising results in understanding stress responses in animal models, but this specific approach to studying sex differences in CRH neuron circuits is relatively novel.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TASKER, JEFFREY G — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: TASKER, JEFFREY G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.