How stress affects alcohol use and the immune system
Neuroimmune mechanisms in stress and alcohol comorbidity
This study is looking at how stress and anxiety can affect drinking habits and how a specific immune protein might play a role in this connection, so if you have anxiety or alcohol use issues, your participation could help us understand these links better and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10650796 on NIH RePORTER |
What this research studies
This research investigates the relationship between stress, anxiety disorders, and alcohol use disorders (AUDs). It focuses on how immune-related pathways, particularly the role of a cytokine called Interleukin-18, influence brain function and behavior related to anxiety and alcohol consumption. By examining the cellular mechanisms in the amygdala, a brain region involved in emotional responses, the study aims to understand how stress and alcohol exposure can lead to increased anxiety and addiction. Patients may be involved in assessments that explore these biological connections and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of anxiety disorders, such as PTSD, who also experience alcohol use issues.
Not a fit: Patients without any history of anxiety disorders or alcohol use problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals struggling with alcohol use disorders and anxiety, improving their overall mental health and quality of life.
How similar studies have performed: Previous studies have shown promising results in understanding the role of immune pathways in anxiety and addiction, suggesting that this research builds on established findings.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Roberto, Marisa — Scripps Research Institute, the
- Study coordinator: Roberto, Marisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.