How stress-activated neutrophils affect tumor recurrence
Regulation of tumor recurrence by stress activated neutrophils
This study is looking at how stress can affect certain immune cells and help hidden cancer cells come back after surgery, with the hope of finding better treatments to keep cancer from returning.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11011310 on NIH RePORTER |
What this research studies
This research investigates the role of stress-activated neutrophils in the recurrence of tumors, particularly after surgical removal of cancerous lesions. It focuses on understanding how certain tumor cells can remain dormant and later reactivate, leading to local or distant metastases. By modeling tumor cell dormancy through the regulation of the p53 tumor suppressor gene, the research aims to uncover the mechanisms that allow these dormant cells to evade treatment and cause cancer recurrence. Patients may benefit from insights that could lead to improved therapies targeting these dormant cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with early-stage non-small cell lung cancer who have undergone surgical resection.
Not a fit: Patients with advanced-stage cancer or those who have not undergone surgical treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing tumor recurrence in cancer patients.
How similar studies have performed: Other research has shown promising results in understanding tumor dormancy and recurrence, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Zhang, Rugang — University of Tx Md Anderson Can Ctr
- Study coordinator: Zhang, Rugang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.