How stigma and social factors affect TB detection and care
Multi-level and Intersectional Stigma and other Social Determinant Effects on TB Case Detection, Care, and Treatment Outcomes: The MISSED TB Outcomes Study
['FUNDING_R01'] · DESMOND TUTU HIV FOUNDATION · NIH-11031416
This project looks at how community and personal stigma and other social barriers affect whether people with TB—many living with HIV—get tested, start treatment, and complete care in South Africa.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DESMOND TUTU HIV FOUNDATION (nih funded) |
| Locations | 1 site (CAPE TOWN, SOUTH AFRICA) |
| Trial ID | NIH-11031416 on ClinicalTrials.gov |
What this research studies
We will work in Cape Town communities and follow people who live with someone with TB and symptomatic household contacts who are referred for testing. You may be asked to complete surveys, take part in interviews, and be followed over time to see if you get tested, start treatment, and finish care. The team will combine household-level surveys to measure community attitudes with interviews that explore experiences of stigma and other social challenges. Researchers will link these data to clinical follow-up to find where people are being missed along the care pathway.
Who could benefit from this research
Good fit: Ideal participants are household contacts of people with TB in the Cape Town study communities, especially symptomatic contacts and people living with HIV.
Not a fit: People who do not live in the study communities, have no TB exposure, or receive care in very different health systems may not directly benefit from this specific project.
Why it matters
Potential benefit: If successful, the work could lead to programs that reduce stigma and other barriers so more people with TB (including those with HIV) are diagnosed early and complete treatment.
How similar studies have performed: Qualitative studies have shown stigma affects TB care, but few have measured these effects prospectively across the full care cascade, so this is a relatively new, comprehensive approach.
Where this research is happening
CAPE TOWN, SOUTH AFRICA
- DESMOND TUTU HIV FOUNDATION — CAPE TOWN, SOUTH AFRICA (ACTIVE)
Researchers
- Principal investigator: MEDINA-MARINO, ANDREW — DESMOND TUTU HIV FOUNDATION
- Study coordinator: MEDINA-MARINO, ANDREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus