How steroid hormones affect learning and memory during aging
Regulation of learning and memory by steroid hormone signaling during development and aging
This study is looking at how a substance called kynurenic acid affects learning and memory as we get older, using tiny worms to see if lowering its levels can help improve learning, especially in older folks, and whether a hormone might make this effect even better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11080337 on NIH RePORTER |
What this research studies
This research investigates the role of kynurenic acid (KYNA) in learning and memory, particularly how its levels change with age and impact cognitive function. Using the model organism C. elegans, the study explores how reducing KYNA can enhance learning capabilities, especially in aged individuals. The researchers are also examining a steroid hormone called androst-5-ene-3β,17β-diol (ADIOL) to see if it can further improve learning by interacting with KYNA and specific brain receptors. The goal is to uncover molecular mechanisms that could lead to new treatments for cognitive decline associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or memory issues.
Not a fit: Patients with cognitive impairments not related to aging or neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cognitive function and memory in aging individuals.
How similar studies have performed: Previous studies in both C. elegans and mice have shown promising results in improving learning and memory through similar approaches.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Ashrafi, Kaveh — University of California, San Francisco
- Study coordinator: Ashrafi, Kaveh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.