How steroid hormones affect brain circuits involved in behavior and sensory processing
Steroid Hormone-Regulated Plasticity of Sensorimotor Integration Circuitry Supports Behavioral Change
['FUNDING_FELLOWSHIP'] · WASHINGTON UNIVERSITY · NIH-10995613
This study looks at how steroid hormones affect the brain's ability to connect what we sense with what we do, using electric fish as a model, and it hopes to shed light on how these processes might relate to challenges faced by people with conditions like autism and schizophrenia.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10995613 on ClinicalTrials.gov |
What this research studies
This research investigates how steroid hormones influence the brain circuits that integrate sensory and motor signals, particularly focusing on corollary discharges (CD) in mormyrid electric fish. By examining how these hormones alter neuronal activity, the study aims to understand the mechanisms that allow animals to predict sensory feedback from their own actions. This could provide insights into behavioral and sensory deficits seen in conditions like autism and schizophrenia. The research employs advanced techniques to analyze the effects of hormones on neuronal signaling and behavior in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related sensory processing issues.
Not a fit: Patients without autism or related sensory processing disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving sensory processing and behavioral outcomes in individuals with autism and related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of hormones in sensory processing, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JARZYNA, MARTIN WILLIAM — WASHINGTON UNIVERSITY
- Study coordinator: JARZYNA, MARTIN WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder