How stem cells use glucose for blood cell formation
The role of glycolysis and glucose oxidation in hematopoiesis
This study is looking at how special blood-making cells use sugar and other nutrients to grow and develop, helping us learn more about how different types of blood cells are made.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11014949 on NIH RePORTER |
What this research studies
This research investigates how hematopoietic stem cells, which are responsible for producing blood cells, metabolize glucose and other nutrients in the body. By developing new methods to analyze these rare cells, the researchers aim to understand the differences in nutrient metabolism between various types of blood cell progenitors. The study involves tracing labeled nutrients to see how they are processed in living organisms, particularly focusing on the role of glycolysis and the TCA cycle in blood cell development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting blood cell production or those interested in understanding blood cell development.
Not a fit: Patients with established blood disorders that do not involve hematopoietic stem cell function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into blood cell formation and potential treatments for blood disorders.
How similar studies have performed: Other research has shown promising results in understanding stem cell metabolism, but this approach is novel in its focus on in vivo glucose metabolism in hematopoietic stem cells.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Agathocleous, Michalis — Ut Southwestern Medical Center
- Study coordinator: Agathocleous, Michalis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.