How statins may help prevent and treat liver cancer
Molecular Mechanisms by which Statins Prevent and Reverse Hepatocellular Carcinoma
This study is looking at how statins, which are often used to lower cholesterol, might help prevent and treat liver cancer, and it’s for anyone interested in new ways to fight this serious disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10931574 on NIH RePORTER |
What this research studies
This research investigates how statins, commonly used to lower cholesterol, can prevent and treat hepatocellular carcinoma (HCC), a serious type of liver cancer. The study will explore the mechanisms by which statins inhibit cancer growth, particularly focusing on their effects on a specific cancer-related protein called MYC. By using advanced mouse models, researchers aim to identify biomarkers that can predict how well patients might respond to statin treatment. This could lead to new strategies for using statins in cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with hepatocellular carcinoma.
Not a fit: Patients with liver cancer types other than hepatocellular carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic approach for patients with liver cancer, potentially improving survival rates.
How similar studies have performed: Previous studies have shown promising results regarding the use of statins in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Felsher, Dean W — Stanford University
- Study coordinator: Felsher, Dean W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.