How splicing regulators affect brain function and disorders
Regulation of Alternative Splicing in the Brain by a Large Assembly of Splicing Regulators
This study is looking at how certain proteins in the brain help control the way genes are switched on and off, which is important for brain function, and it hopes to find out how this process is linked to conditions like autism and epilepsy, so we can better understand what causes these disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10862794 on NIH RePORTER |
What this research studies
This research investigates the role of a group of proteins called Rbfox in regulating alternative splicing in the brain, which is crucial for its complexity and function. By studying how these proteins interact with other splicing regulators, the research aims to uncover the mechanisms behind certain neurological and psychiatric disorders, including autism spectrum disorder and epilepsy. The approach involves identifying the components of a large assembly of splicing regulators and analyzing their effects on gene regulation in neurons. This could lead to a better understanding of how genetic mutations contribute to these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or familial epilepsy, particularly those with known genetic mutations affecting RNA binding proteins.
Not a fit: Patients with neurological disorders not linked to alternative splicing or RNA binding protein mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the molecular mechanisms underlying autism and epilepsy, potentially leading to new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA binding proteins in neurological disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Peyda, Parham — University of California Los Angeles
- Study coordinator: Peyda, Parham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.