How sperm prepare for fertilization
Comparative studies on the regulation of metabolism during sperm capacitation
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11101366
This research explores how sperm change and get energy to become ready for fertilization, which could help people facing infertility.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11101366 on ClinicalTrials.gov |
What this research studies
Sperm need to change and get energy to successfully fertilize an egg, a process called capacitation that happens as they travel through the reproductive tract. This project looks closely at how sperm use different nutrients and regulate their energy pathways to complete these crucial steps. Researchers are also focusing on a key molecule, soluble adenylyl cyclase (sAC), which plays an essential role in these changes. By understanding these detailed metabolic processes, we hope to uncover new insights into male fertility.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patient participation, but future clinical applications could benefit individuals or couples experiencing male infertility.
Not a fit: Patients not experiencing male infertility or those not seeking assisted reproductive technologies may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to understand and address male infertility, potentially improving assisted reproductive technologies.
How similar studies have performed: Previous work by this team has shown how sperm use glucose and other energy sources during capacitation, building a foundation for this deeper investigation.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCK, JOCHEN — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: BUCK, JOCHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.