How specific proteins control the development of different types of neurons in the brain and spinal cord
Transcription Factor Control of Neuronal Diversity
['FUNDING_R37'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11013363
This study is looking at how specific proteins help shape the balance of different types of nerve cells in the brain, which could lead to better understanding and treatment of neurological conditions related to these cells.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11013363 on ClinicalTrials.gov |
What this research studies
This research investigates how certain proteins, known as transcription factors, influence the development of inhibitory and excitatory neurons in the nervous system. By examining the roles of PTF1A and PRDM13, the study aims to understand how these proteins regulate the balance of neuron types during early development. The research involves detailed molecular and cellular analyses, as well as behavioral assessments, to uncover the mechanisms behind neuron specification. Patients may benefit from insights gained into neurological conditions related to imbalances in these neuron types.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurological conditions related to inhibitory and excitatory neuron imbalances.
Not a fit: Patients with neurological conditions unrelated to the development or function of inhibitory and excitatory neurons may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders caused by imbalances in neuronal types.
How similar studies have performed: Other research has shown success in understanding the roles of transcription factors in neuronal development, indicating that this approach is promising.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, JANE E — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: JOHNSON, JANE E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.