How specific proteins control energy production in a common fungal pathogen.
Control of Mitochondrial Function by SPFH Proteins in Pathogenic Yeast
['FUNDING_OTHER'] · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · NIH-10916270
This study is looking at how certain proteins in a common fungus called Candida albicans help it survive tough conditions and resist treatments, with the hope that understanding this could lead to new ways to fight fungal infections in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHN JAY COLLEGE OF CRIMINAL JUSTICE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10916270 on ClinicalTrials.gov |
What this research studies
This research investigates the role of SPFH proteins in the mitochondria of Candida albicans, a prevalent fungal pathogen in humans. By examining how these proteins affect mitochondrial function, the study aims to uncover mechanisms that allow the fungus to survive environmental stress and resist antifungal treatments. The research employs advanced techniques, including CRISPR, to manipulate gene expression and analyze the resulting effects on the fungus's energy production and pathogenicity. Patients may benefit from insights gained into new antifungal therapies that target these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals suffering from recurrent or severe Candida infections.
Not a fit: Patients with fungal infections caused by organisms other than Candida albicans may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antifungal treatments for infections caused by Candida albicans.
How similar studies have performed: While the specific approach of targeting SPFH proteins in Candida albicans is novel, similar research has shown promise in understanding mitochondrial functions in other pathogens.
Where this research is happening
NEW YORK, UNITED STATES
- JOHN JAY COLLEGE OF CRIMINAL JUSTICE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RAUCEO, JASON MALCOLM — JOHN JAY COLLEGE OF CRIMINAL JUSTICE
- Study coordinator: RAUCEO, JASON MALCOLM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.