How specific microRNAs influence the development of brain connections in mammals
Official title: An evolutionarily acquired microRNA cluster shapes development of mammalian cortical projections
Funded at Stanford University · NIH-10991835 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs help shape important connections in the brain that affect movement and thinking, which could lead to better understanding and treatments for conditions like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $353,483 |
| NIH project number | 5R01NS134969-02 |
| Project ID | NIH-10991835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not related to the mechanisms being studied may not receive benefit from this research.
What this research studies
This research investigates the role of a specific cluster of microRNAs in the development of brain projections that are crucial for motor and cognitive functions. By examining how these microRNAs influence the fate of certain neurons, the study aims to uncover the mechanisms behind the formation of distinct neural pathways. The researchers will use advanced techniques such as deep sequencing and in vivo functional perturbation to explore how these microRNAs regulate axon guidance pathways, potentially leading to a better understanding of brain development. Patients may benefit from insights gained into conditions like autism spectrum disorder, which may be linked to these developmental processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders, including autism spectrum disorder.
How similar studies have gone: Other research has shown promise in understanding the role of microRNAs in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Tharin, Suzanne Audrey — Stanford University
- Study coordinator: Tharin, Suzanne Audrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.