How specific ion channels and cell structures affect heart rhythm
Official title: Distinct Ion Channel Pools and Intercalated Disk Nanoscale Structure Regulate Cardiac Conduction
Funded at Ohio State University · NIH-11021075 · Data updated 2026-11-12
This study is looking at tiny structures in heart cells that help keep your heartbeat steady, and it aims to understand how problems with these structures might cause irregular heart rhythms, which could lead to new ways to treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 20, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $663,775 |
| NIH project number | 5R01HL165751-03 |
| Project ID | NIH-11021075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cardiac arrhythmias or those at risk for heart rhythm disorders.
✕Less likely to help
Patients with non-cardiac related health issues or those without any history of heart rhythm problems may not benefit from this research.
What this research studies
This research investigates the unique pools of ion channels located at the intercalated disks of heart cells, which are crucial for maintaining proper heart rhythm and conduction. By using advanced microscopy and computational modeling, the study aims to understand how these ion channels and their nanoscale structures influence cardiac function. The research will also explore how disruptions in these structures may lead to arrhythmias, providing insights into potential new treatments for heart rhythm disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with cardiac arrhythmias, enhancing heart health and reducing the risk of serious complications.
How similar studies have gone: Previous research has shown promising results in understanding cardiac conduction through similar approaches, indicating a potential for significant advancements in this area.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Weinberg, Seth Howard — Ohio State University
- Study coordinator: Weinberg, Seth Howard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.