How specific genetic variants affect immune response in Alzheimer's disease
Impact of PLCG2 Alzheimer's Disease Risk Variants on Microglia Biology and Disease Pathogenesis
This study is looking at how certain genetic changes in the PLCG2 gene affect the immune cells in the brain and their role in Alzheimer's disease, hoping to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10884081 on NIH RePORTER |
What this research studies
This research investigates the role of genetic variants in the PLCG2 gene and their impact on microglial function in Alzheimer's disease (AD). By using rodent models, the study aims to understand how these variants influence the immune response associated with AD pathogenesis. The researchers will explore both protective and risk-associated variants to determine their effects on disease progression and microglial behavior. This comprehensive analysis could provide insights into potential therapeutic targets for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those identified as having genetic risk factors for the condition.
Not a fit: Patients with Alzheimer's disease who do not have the specific PLCG2 genetic variants being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting specific genetic factors.
How similar studies have performed: Previous research has shown success in understanding genetic factors in Alzheimer's disease, making this approach both relevant and promising.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Lamb, Bruce T — Indiana University Indianapolis
- Study coordinator: Lamb, Bruce T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.