How specific genetic mutations change type 1 diabetes risk in a mouse model
Modulation of NOD Strain Diabetes by ENU-Induced Mutations
['FUNDING_P01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11096024
Researchers are creating and tracking genetic changes in mice to find the genes that make type 1 diabetes more or less likely.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11096024 on ClinicalTrials.gov |
What this research studies
The team uses Non-Obese Diabetic (NOD) mice, a model that mirrors many features of human type 1 diabetes, and introduces point mutations with a chemical mutagen called ENU. They breed and monitor mouse pedigrees to see which mutations raise or lower the chance of developing diabetes. A technology platform lets them quickly identify the exact mutations responsible for those effects. By mapping these genetic modifiers, researchers aim to link mouse findings to pathways that could inform future human treatments or biomarkers.
Who could benefit from this research
Good fit: This project does not enroll human participants; people with type 1 diabetes are not study subjects here but could be future beneficiaries of downstream clinical research based on these findings.
Not a fit: Because the work is preclinical and performed in mice, patients should not expect direct or immediate treatment benefits from this project.
Why it matters
Potential benefit: Could reveal genes and biological pathways that point to new targets for preventing or treating type 1 diabetes in people.
How similar studies have performed: Previous genetic screens in NOD mice, including ENU mutagenesis, have identified gene modifiers that change diabetes risk in mice, though moving those discoveries into human treatments has been slow.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEUTLER, BRUCE A — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: BEUTLER, BRUCE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diabetes