How specific brain cells control pathways in the hippocampus
Interneurons differentially regulate discrete pathways from ventral hippocampus
This study is looking at how certain brain cells help control the activity of other important brain cells in a part of the brain called the ventral hippocampus, which could help us understand and find new treatments for conditions like Alzheimer's and other mental health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-10634672 on NIH RePORTER |
What this research studies
This research investigates the role of specific types of inhibitory brain cells, known as interneurons, in regulating the activity of excitatory cells in the ventral hippocampus, which is crucial for various brain functions. By using advanced techniques like fiber photometry and optogenetics, the study aims to understand how these interneurons influence the behavior of pyramidal cells based on their target areas in the brain. This could provide insights into the underlying mechanisms of neurological disorders, including Alzheimer's disease and other mental health conditions, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with non-neurological conditions or those without cognitive impairments may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Alzheimer's disease and related neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of interneurons in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Donegan, Jennifer — University of Texas at Austin
- Study coordinator: Donegan, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.