How specific brain cells affect memory formation in healthy individuals and those with Alzheimer's disease
Hippocampal interneurons in novel memory formation in health and Alzheimer's disease
This study is looking at how certain brain cells help us remember where we are and how problems with these cells might affect memory in people with Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10512199 on NIH RePORTER |
What this research studies
This research investigates the role of hippocampal interneurons, particularly parvalbumin-positive interneurons, in the formation of spatial memories. It aims to understand how these cells contribute to memory processes and how their dysfunction may lead to memory impairments in Alzheimer's disease. By using advanced techniques to record and manipulate the activity of these neurons, the study seeks to clarify their role in memory formation and the impact of Alzheimer's pathology on these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with early-stage Alzheimer's disease or those experiencing memory impairments.
Not a fit: Patients with advanced Alzheimer's disease or those without any memory-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of interneurons in memory, but this specific approach focusing on parvalbumin-positive interneurons in the context of Alzheimer's disease is relatively novel.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Singer, Annabelle Catherine — Georgia Institute of Technology
- Study coordinator: Singer, Annabelle Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.