How special immune cells protect babies and young children from malaria
The role of γδ T cells in fetal and infant immune defense against malaria
This research explores how a unique type of immune cell, called gamma delta T cells, helps protect babies and young children from malaria infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11089361 on NIH RePORTER |
What this research studies
Our bodies have special immune cells called gamma delta T cells that develop very early, even before birth. These cells are different from other immune cells because they can quickly recognize and fight off certain infections, like malaria, without needing prior exposure. We are looking into how these specific gamma delta T cells in infants and young children might act as a ready-made defense against malaria, especially since their immune systems are still developing. Understanding this natural protection could help us find new ways to keep children safe from this disease.
Who could benefit from this research
Good fit: Ideal candidates for related future studies would be infants and young children living in areas where malaria is common, such as Sub-Saharan Africa.
Not a fit: Patients who are adults or not at risk for malaria infection would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or treating malaria in vulnerable infants and young children.
How similar studies have performed: Previous findings suggest that these specific gamma delta T cells can inhibit malaria parasites in lab settings and are linked to protection from malaria in people.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Feeney, Margaret E — University of California, San Francisco
- Study coordinator: Feeney, Margaret E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.