How special cilia in the brain help produce cerebrospinal fluid
Choroid Plexus Multi-Sensory Cilia Regulate Production of Cerebrospinal Fluid
This study is looking at tiny hair-like structures in the brain that help produce the fluid that keeps your brain healthy, and it aims to find out how they work and what that means for conditions like hydrocephalus, so we can learn more about keeping your brain in good shape.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11004127 on NIH RePORTER |
What this research studies
This research investigates the role of multi-sensory cilia in the choroid plexus, a structure in the brain responsible for producing cerebrospinal fluid (CSF). By using advanced imaging techniques, the study aims to understand how these cilia function and their impact on CSF production, which is crucial for brain health and development. The research will explore the connection between cilia and signaling pathways that regulate fluid movement, potentially revealing new insights into conditions like hydrocephalus. Patients may benefit from a better understanding of how CSF production is regulated and how it affects neurological health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions affecting cerebrospinal fluid dynamics, such as hydrocephalus or other ciliopathies.
Not a fit: Patients with unrelated neurological conditions that do not involve cerebrospinal fluid production may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to cerebrospinal fluid production and regulation.
How similar studies have performed: Other research has shown promising results in understanding the role of cilia in various biological processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: He, Lin — University of California Berkeley
- Study coordinator: He, Lin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.