How SNAI1 and AR work together in prostate cancer spread and growth
Coordinated Actions of SNAI1 and AR in Prostate Cancer Dissemination and Metastatic Outgrowth
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF ARIZONA · NIH-10880316
This study is looking at how two important factors, SNAI1 and the androgen receptor, work together to help prostate cancer cells spread and grow in other parts of the body, with the goal of finding better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10880316 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of SNAI1 and the androgen receptor (AR) in the spread and growth of prostate cancer cells. It focuses on understanding how these two factors interact during the late stages of cancer metastasis, particularly how they influence the seeding of cancer cells in distant organs and their subsequent growth. By examining the mechanisms of epithelial-mesenchymal transition (EMT) and its impact on cancer cell behavior, the research aims to uncover new insights that could lead to improved treatment strategies for prostate cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced prostate cancer, particularly those experiencing metastasis.
Not a fit: Patients with early-stage prostate cancer or those whose cancer is not metastatic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that prevent the spread of prostate cancer and improve patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the roles of EMT and AR in cancer, but this specific coordination in prostate cancer is still being explored.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRAN, JACK — UNIVERSITY OF ARIZONA
- Study coordinator: TRAN, JACK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
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