How small nucleolar RNAs contribute to worsening heart disease
Mechanisms by which Small Nucleolar RNAs Exacerbate Atherosclerosis
This study is looking at how tiny molecules called small nucleolar RNAs might contribute to heart disease by increasing stress and inflammation in blood vessels, and it hopes to find new ways to help treat heart problems for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10863975 on NIH RePORTER |
What this research studies
This research investigates the role of small nucleolar RNAs in promoting atherosclerosis, a condition that leads to heart disease. The study aims to identify mechanisms that increase oxidative stress and inflammation in blood vessels while minimizing negative effects on the immune system. By using genetically modified mice, researchers will explore how these RNAs affect the levels of reactive oxygen species and the development of atherosclerosis. Patients may benefit from insights that could lead to new treatments for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with non-cardiovascular diseases or those not at risk for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that reduce heart disease risk by targeting specific RNA mechanisms.
How similar studies have performed: Previous research has shown promising results in targeting oxidative stress in cardiovascular diseases, suggesting potential for success in this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Freedman, Neil J. — Duke University
- Study coordinator: Freedman, Neil J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.