How small airways affect mucus transport in the lungs
Contribution of Small Airways to Mucociliary Transport Dysfunction
This study is looking at how small airways in the lungs help move mucus, which is important for keeping our lungs healthy, especially for people with conditions like cystic fibrosis and asthma, to find better ways to treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11011347 on NIH RePORTER |
What this research studies
This research investigates the role of small airways in the lungs and how they contribute to mucociliary transport dysfunction, which is a critical defense mechanism against respiratory infections. The study aims to understand the mechanisms behind mucus transport in both healthy and diseased states, particularly in conditions like cystic fibrosis and asthma. By examining the interactions between mucus and airway structures, the research seeks to uncover new insights that could lead to improved treatments for airway diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cystic fibrosis, asthma, or other airway diseases that may involve mucociliary dysfunction.
Not a fit: Patients with non-respiratory conditions or those without any airway disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with airway diseases, improving their lung function and quality of life.
How similar studies have performed: While the role of large airways in mucociliary transport has been studied, the specific focus on small airways in relation to airway diseases is relatively novel and has not been extensively tested.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Abou Alaiwa, Mahmoud — University of Iowa
- Study coordinator: Abou Alaiwa, Mahmoud
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.