How sleep problems affect brain changes in early Alzheimer's disease
Linking Sleep Disruption to Tau Accumulation and Network Dysregulation in Early Alzheimer's Disease
This study is looking at how sleep problems might affect the buildup of certain proteins in the brains of people with early Alzheimer's disease, specifically those with Mild Cognitive Impairment, to find ways to help improve their sleep and brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10843901 on NIH RePORTER |
What this research studies
This research investigates the relationship between sleep disruption and the accumulation of tau proteins in the brains of individuals with early Alzheimer's disease. By examining how different aspects of sleep may influence cognitive decline and brain network function, the study aims to identify potential targets for intervention. Participants will be monitored for changes in sleep patterns and cognitive performance over time, providing insights into the progression of Alzheimer's disease. The research focuses specifically on individuals with Mild Cognitive Impairment (MCI), a precursor to Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Mild Cognitive Impairment (MCI) who are experiencing sleep disruptions.
Not a fit: Patients with advanced Alzheimer's disease or those without sleep disruption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing cognitive decline in patients with early Alzheimer's disease.
How similar studies have performed: Previous research has shown promising links between sleep disruption and Alzheimer's pathology, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chhatwal, Jasmeer P — Massachusetts General Hospital
- Study coordinator: Chhatwal, Jasmeer P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.