How sleep patterns affect success in opioid treatment
Official title: Value of Sleep Metrics in Predicting Opioid-Use Disorder Treatment Outcomes: Leadership and Data Coordinating Center
Funded at Harvard Pilgrim Health Care, INC. · NIH-11179444 · Data updated 2026-11-12
This project uses sleep and body‑clock measurements in people with opioid-use disorder to help identify who is likely to stay in medication treatment.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Pilgrim Health Care, INC. NIH-funded |
| Lab location | 1 site (Canton, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $615,199 |
| NIH project number | 5U01DA059472-03 |
| Project ID | NIH-11179444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with opioid-use disorder who are starting or recently started medication treatment and are willing to provide sleep data (surveys or wearable data) and health information.
✕Less likely to help
People not on medication for OUD, those unwilling or unable to share sleep or health data, or children and adolescents are unlikely to benefit from this project.
What this research studies
You would share sleep information such as questionnaires and wearable sleep data while starting medication for opioid-use disorder. The project combines these sleep and circadian measures with other health and risk factors collected across multiple treatment sites through a central data coordinating center. Researchers will analyze early-recovery sleep patterns to find signals linked to staying engaged in treatment. The aim is to use those signals to guide extra support for people at higher risk of dropping out.
Why it matters
Potential benefit: If successful, this could help clinicians spot patients at higher risk of leaving treatment and offer sleep-focused or timing-based supports to improve retention.
How similar studies have gone: Previous research links sleep problems to higher dropout from opioid treatment, but using detailed sleep and circadian measures across many sites to predict outcomes is relatively new.
Where this research is happening
-
Harvard Pilgrim Health Care, INC.
Canton, United States Active
Researchers
- Principal investigator: Wang, Rui — Harvard Pilgrim Health Care, INC.
- Study coordinator: Wang, Rui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.