How sleep loss affects brain injury in Alzheimer's disease
Cellular and Molecular Basis of Sleep Loss Neural Injury in Alzheimer Disease
This study is looking at how not getting enough sleep might affect the worsening of Alzheimer's disease by checking how it influences certain proteins in the brain, and it's designed for anyone interested in understanding the connection between sleep and brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10795099 on NIH RePORTER |
What this research studies
This research investigates the impact of chronic short sleep on the progression of Alzheimer's disease, particularly focusing on how sleep deprivation influences tau protein accumulation in the brain. The study uses a murine model to explore the biochemical and behavioral changes associated with sleep loss, examining the role of specific neurons that are vulnerable in Alzheimer's. By understanding these mechanisms, the research aims to identify potential therapeutic targets to mitigate the effects of sleep loss on brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing chronic short sleep and showing early signs of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease in individuals suffering from sleep loss.
How similar studies have performed: Previous research has indicated that sleep loss can exacerbate neurodegenerative conditions, suggesting that this approach may yield valuable insights into Alzheimer's disease.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Veasey, Sigrid C — University of Pennsylvania
- Study coordinator: Veasey, Sigrid C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.