How sleep health affects Alzheimer's disease and cognitive decline
Official title: Biological pathways linking sleep health to Alzheimers disease and cognitive decline
Funded at University of California Los Angeles · NIH-10887078 · Data updated 2026-11-12
This study is looking at how sleep problems, like not getting enough sleep or having insomnia, might increase the risk of developing Alzheimer's disease and memory issues, and it aims to find clues in our biology that could help us understand this connection better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $129,249 |
| NIH project number | 1K01AG081542-01A1 |
| Project ID | NIH-10887078 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing sleep issues, particularly those with insomnia or short sleep duration, who are at risk for cognitive decline or Alzheimer's disease.
✕Less likely to help
Patients who do not have sleep issues or are not at risk for cognitive decline or Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between sleep health and the risk of developing Alzheimer's disease and cognitive decline. It focuses on understanding how poor sleep, particularly insomnia combined with short sleep duration, may disrupt biological pathways linked to these conditions. By employing a multi-omics approach, the study aims to analyze various biological data to uncover potential biomarkers for Alzheimer's disease. The research will involve collaboration with experts in sleep and Alzheimer's research to ensure a comprehensive analysis.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how improving sleep health may reduce the risk of Alzheimer's disease and cognitive decline.
How similar studies have gone: Previous research has shown promising results linking sleep health to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Kusters, Cynthia Diana Johanna — University of California Los Angeles
- Study coordinator: Kusters, Cynthia Diana Johanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.