How sleep apnea affects thinking in older people with schizophrenia
Official title: Cognitive Consequences of Obstructive Sleep Apnea in Schizophrenia: An Investigation of Inflammatory Mechanisms
Funded at University of California, San Diego · NIH-11021103 · Data updated 2026-11-12
This study is looking at how sleep apnea might affect thinking skills in older adults with schizophrenia, and it hopes to find clues that could help improve brain health for people in this situation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $634,616 |
| NIH project number | 5R01MH135147-02 |
| Project ID | NIH-11021103 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults (65 years and older) diagnosed with schizophrenia who may also have obstructive sleep apnea.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those under 65 years of age may not benefit from this research.
What this research studies
This research investigates the impact of obstructive sleep apnea (OSA) on cognitive function in older adults with schizophrenia. It aims to understand how inflammation related to OSA may contribute to cognitive decline and identify potential biomarkers for these effects. By comparing individuals with schizophrenia to a non-psychiatric group, the study will gather data on sleep patterns, cognitive abilities, and inflammatory markers. The findings could inform future interventions to improve cognitive health in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive dysfunction in older adults with schizophrenia.
How similar studies have gone: Previous research has shown that addressing sleep apnea can improve cognitive outcomes in various populations, suggesting potential success for similar approaches in this study.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Lee, Ellen Eun-Ok — University of California, San Diego
- Study coordinator: Lee, Ellen Eun-Ok
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.