How sleep apnea affects memory and tau buildup in the brain
Impact of sleep apnea and its treatment on memory and tau accumulation in the brain
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10808925
This study is looking at how sleep apnea might affect memory and brain health in older adults, especially in relation to Alzheimer's disease, by checking how sleep problems relate to changes in brain proteins and memory over time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10808925 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between sleep apnea and its impact on memory and tau protein accumulation in the brain, particularly in older adults. It aims to understand how sleep disruption may contribute to cognitive decline and the development of Alzheimer's disease. The study will analyze the severity of obstructive sleep apnea and its correlation with changes in tau levels and memory performance over time. By examining cerebrospinal fluid samples and cognitive assessments, the research seeks to uncover potential mechanisms linking sleep apnea to neurodegenerative processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who experience symptoms of sleep apnea and are cognitively normal.
Not a fit: Patients who do not have sleep apnea or significant cognitive concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive decline associated with sleep apnea and Alzheimer's disease.
How similar studies have performed: Previous research has indicated a link between sleep apnea and cognitive decline, suggesting that this study builds on established findings rather than exploring an entirely novel approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VARGA, ANDREW W — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: VARGA, ANDREW W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.