How sleep affects migraines and vice versa
Official title: Adenosine Modulation of the Bi-Directional Relationship between Sleep and Migraine
Funded at University of California Los Angeles · NIH-11055397 · Data updated 2026-11-12
This study is looking at how sleep affects migraines and how migraines can affect sleep, using animal models to find out more about the brain's activity, with the hope of discovering new ways to help people manage their migraines better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $287,415 |
| NIH project number | 5K01NS127944-02 |
| Project ID | NIH-11055397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who experience migraines and have sleep disturbances.
✕Less likely to help
Patients who do not suffer from migraines or have no sleep-related issues may not benefit from this research.
What this research studies
This research investigates the complex relationship between sleep and migraines, focusing on how sleep patterns can influence migraine occurrences and vice versa. The study will utilize advanced techniques to monitor brain activity in animal models, aiming to uncover the specific biological mechanisms involved. By examining the role of astrocytes and adenosine signaling, the research seeks to identify potential new treatments that could help manage migraines more effectively. This work is led by a pediatric neurologist specializing in headache and pain medicine, ensuring a strong clinical perspective.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from migraines by improving our understanding of how sleep affects migraine conditions.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between sleep and migraines, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Nwaobi, Sinifunanya Elvee — University of California Los Angeles
- Study coordinator: Nwaobi, Sinifunanya Elvee
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.