How sleep affects memory storage in the brain
Linking interneuron-mediated circuit regulation with sleep-dependent plasticity and memory storage in the hippocampus
This study is looking at how sleep helps our brains remember things better by exploring how certain brain cells in mice react to sleep and lack of sleep, which could help us understand why getting enough rest is important for learning and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10896228 on NIH RePORTER |
What this research studies
This research investigates the role of sleep in memory consolidation, focusing on specific brain circuits in the hippocampus. By using a mouse model, the study examines how different types of interneurons respond to sleep and sleep deprivation, and how these responses influence memory retention. The researchers will manipulate these interneurons using advanced techniques to observe changes in brain activity and structure related to memory. This approach aims to uncover the mechanisms behind sleep's impact on learning and memory.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with sleep disorders or cognitive impairments, particularly those related to memory.
Not a fit: Patients who do not experience sleep-related memory issues or cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing memory and cognitive function in individuals affected by sleep disorders or memory impairments.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between sleep and memory, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Aton, Sara J — University of Michigan at Ann Arbor
- Study coordinator: Aton, Sara J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.