How sleep affects immune response in people with HIV
Official title: Understanding the association of sleep on monocyte action in HIV infection
Funded at Case Western Reserve University · NIH-11196307 · Data updated 2026-11-12
This study is looking at how sleep problems, like not getting enough sleep or having sleep apnea, can affect the immune system and heart health in people living with HIV, with the hope of finding ways to improve sleep and overall health for these individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $189,368 |
| NIH project number | 7K23HL169022-02 |
| Project ID | NIH-11196307 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who experience sleep disorders.
✕Less likely to help
Patients who do not have HIV or do not experience sleep disorders may not benefit from this research.
What this research studies
This research investigates the relationship between sleep health and immune function in individuals living with HIV. It focuses on how sleep disorders, such as obstructive sleep apnea and insufficient sleep, may worsen inflammation and increase the risk of cardiovascular disease in these patients. By examining the activation of immune cells called monocytes, the study aims to uncover the mechanisms through which sleep disturbances impact health outcomes. The ultimate goal is to develop sleep-based interventions that could improve the overall health of people with HIV.
Why it matters
Potential benefit: If successful, this research could lead to improved health outcomes and reduced cardiovascular risks for patients living with HIV.
How similar studies have gone: While the specific impact of sleep disorders on monocyte activation in HIV has not been extensively studied, related research has shown that sleep health significantly influences immune function and chronic disease outcomes.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Borker, Priya Vassant — Case Western Reserve University
- Study coordinator: Borker, Priya Vassant
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.