How sleep affects gene expression and chromatin regulation in vertebrates.
The role of sleep on chromatin and transcriptional regulation across vertebrate evolution.
['FUNDING_OTHER'] · WASHINGTON STATE UNIVERSITY · NIH-10915032
This study is looking at how not getting enough sleep affects our genes and cell functions in different animals, which could help us understand why sleep is so important for our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PULLMAN, UNITED STATES) |
| Trial ID | NIH-10915032 on ClinicalTrials.gov |
What this research studies
This research investigates the role of sleep in influencing gene expression and chromatin regulation across different vertebrate species. By comparing the effects of sleep loss on transcriptional responses in various tissues, including the brain, the study aims to uncover conserved mechanisms that have evolved over time. The research employs advanced techniques such as single-cell transcriptomic and epigenomic analysis to achieve high-resolution insights into how different cell types respond to sleep deprivation. This approach could lead to a better understanding of the biological significance of sleep in regulating cellular functions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with sleep disorders or those interested in the biological impacts of sleep on health.
Not a fit: Patients with conditions unrelated to sleep or gene regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of sleep's critical role in gene regulation, potentially leading to new therapeutic strategies for sleep-related disorders.
How similar studies have performed: While there is existing evidence supporting the importance of sleep in gene regulation, this specific comparative approach across vertebrate species is novel and has not been extensively tested.
Where this research is happening
PULLMAN, UNITED STATES
- WASHINGTON STATE UNIVERSITY — PULLMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEIXOTO, LUCIA — WASHINGTON STATE UNIVERSITY
- Study coordinator: PEIXOTO, LUCIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.