How skull malformations affect brain fluid systems in craniosynostosis
Official title: The effects of skull malformations and intracranial hypertension on the glymphatic and meningeal lymphatic systems in craniosynostosis
Funded at Rutgers, the State Univ of N.j. · NIH-10574732 · Data updated 2026-11-12
This study looks at how craniosynostosis, a condition that affects the shape of the skull, influences the flow of fluid in the brain and could help us understand why some kids with this condition might have trouble with thinking and learning.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $302,318 |
| NIH project number | 1R03DE032409-01 |
| Project ID | NIH-10574732 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with craniosynostosis who may experience cognitive issues related to raised intracranial pressure.
✕Less likely to help
Patients without craniosynostosis or those who do not experience cognitive impairments may not benefit from this research.
What this research studies
This research investigates the impact of craniosynostosis, a condition characterized by skull malformations, on the brain's fluid circulation systems. It focuses on how raised intracranial pressure affects cerebrospinal fluid (CSF) flow and the glymphatic and meningeal lymphatic systems. By using animal models and fluorescent tracers, the study aims to uncover changes in fluid dynamics and waste clearance pathways in the brain. The findings could provide insights into the relationship between craniosynostosis and cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for cognitive impairments associated with craniosynostosis.
How similar studies have gone: While this research explores a novel approach, previous studies have shown the importance of glymphatic and meningeal lymphatic systems in brain health, indicating potential for significant findings.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Tischfield, Max — Rutgers, the State Univ of N.j.
- Study coordinator: Tischfield, Max
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.