How skull bone marrow affects inflammation in the brain
Contribution of the Skull Bone Marrow during Neuroinflammation
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10794908
This study is looking at how certain cells in the brain that help tumors grow, like glioblastoma, use their surroundings to survive, and it hopes to find new ways to treat brain-related issues that involve inflammation, which could help patients in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10794908 on ClinicalTrials.gov |
What this research studies
This research investigates the role of skull bone marrow in neuroinflammation, particularly focusing on its contribution to brain tumors like glioblastoma. The study examines how certain cells in the brain, known as brain tumor initiating cells (BTICs), survive and thrive in challenging environments by utilizing specific metabolic pathways. By understanding the relationship between oxidative stress and metabolism in these cells, the research aims to uncover new treatment strategies for neurological disorders. Patients may benefit from insights that could lead to improved therapies for conditions associated with neuroinflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with glioblastoma or other related neurological conditions.
Not a fit: Patients with non-neurological conditions or those not affected by neuroinflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with brain tumors and other neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of metabolic pathways in brain tumors, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TUY, KAYSAW C — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: TUY, KAYSAW C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autosomal Dominant Segawa Syndrome