How skin stem cells adapt to inflammation during healing
Genetic mapping of the inflammatory adaption circuit in epithelial stem cells
This research explores how the body's skin stem cells manage inflammation to heal wounds effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11140501 on NIH RePORTER |
What this research studies
Our skin and other barrier tissues rely on special stem cells to repair themselves after injury. When you get a wound, immune cells rush in to fight infection, but they also create a harsh, inflammatory environment. This project aims to discover the genetic instructions that allow these important stem cells to survive and thrive in inflammation, ensuring proper healing. Understanding this process could help us find new ways to treat wounds that struggle to close.
Who could benefit from this research
Good fit: Patients who experience chronic or non-healing wounds may eventually benefit from the discoveries made in this fundamental research.
Not a fit: Patients without conditions related to epithelial stem cell function or wound healing may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for chronic, non-healing wounds by helping stem cells better adapt to inflammation.
How similar studies have performed: While previous assumptions suggested stem cells needed protection from inflammation, this project builds on recent findings that show stem cells actively adapt to inflammatory environments.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Miao, Yuxuan Phoenix — University of Chicago
- Study coordinator: Miao, Yuxuan Phoenix
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.