How skin lymphatic drainage controls immune balance in the skin
Dermal Lymphatic Transport and Cutaneous Immune Balance
This project looks at how tiny lymph vessels in the skin turn immune reactions on and off to help people with autoimmune or inflammatory skin conditions and some skin cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11250124 on NIH RePORTER |
What this research studies
Researchers are studying how dermal lymphatic vessels change their structure and how those changes affect the movement of immune cells, antigens, and inflammatory signals in skin. They will use laboratory experiments, animal models, and human skin samples to map how vessel 'zippering' alters immune activation and resolution. One aim examines crosstalk between lymphatic transport and the skin’s inflammatory environment, and another tests how changing lymphatic function shifts immune outcomes. The team aims to find ways to tune lymphatic transport to reduce harmful inflammation or improve anti-tumor immunity.
Who could benefit from this research
Good fit: People with autoimmune skin diseases, chronic inflammatory skin conditions, or certain skin cancers would be the most relevant candidates for related future studies.
Not a fit: Those with medical problems unrelated to skin immune balance or anyone seeking immediate clinical treatments are unlikely to benefit directly from this basic research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce harmful skin inflammation, control autoimmune skin attacks, or boost immune responses against skin cancers.
How similar studies have performed: Previous laboratory and preliminary studies, including the investigators' own work, show lymphatic remodeling affects immune responses, but translating these findings into patient treatments is still novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Lund, Amanda W. — New York University School of Medicine
- Study coordinator: Lund, Amanda W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.