How skin immune cells affect tissue healing and inflammation
Official title: Reprogramming of tissue structural cells by cutaneous CD4+ T cells
Funded at Benaroya Research Inst at Virginia Mason · NIH-11113814 · Data updated 2026-11-12
This study is looking at how certain immune cells in the skin work with skin cells during inflammation, which could help us understand and improve treatments for inflammatory skin conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 19, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $627,326 |
| NIH project number | 5R01AI169893-03 |
| Project ID | NIH-11113814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from inflammatory skin conditions such as atopic dermatitis or allergic eczema.
✕Less likely to help
Patients with non-inflammatory skin conditions or those not affected by skin diseases may not benefit from this research.
What this research studies
This research investigates how cutaneous CD4+ T cells interact with skin structural cells like keratinocytes and fibroblasts during inflammation. It aims to understand how these immune cells can reprogram the behavior and function of skin cells, potentially leading to changes in inflammatory skin diseases. By using advanced cell culture systems and a mouse model, the study will explore the mechanisms behind this interaction and how it influences skin healing and inflammation over time.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inflammatory skin conditions by targeting the underlying mechanisms of tissue reprogramming.
How similar studies have gone: Other research has shown promising results in understanding immune cell interactions with tissue cells, suggesting that this approach could yield significant insights.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Campbell, Daniel J — Benaroya Research Inst at Virginia Mason
- Study coordinator: Campbell, Daniel J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.