How Skin Heals After Injury
Understanding Skin Tissue Repair in Live Mammals
This work explores how different skin cells work together to repair injuries, especially when some cells have genetic changes that can lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11169732 on NIH RePORTER |
What this research studies
Our skin protects us from the outside world, and its ability to heal after an injury is vital for our health. When skin doesn't heal properly, it can lead to chronic wounds, which are serious and can have severe consequences. This project aims to understand how various skin cells, like epithelial cells and fibroblasts, coordinate their actions to repair damaged tissue. We are particularly interested in how genetically diverse cells, including those with mutations linked to skin cancer, influence this healing process. By directly observing and manipulating these cells in live models, we hope to uncover the fundamental ways skin repairs itself.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but future clinical applications could benefit individuals prone to chronic wounds or certain skin cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of chronic wounds and skin cancer development, potentially guiding new strategies for treatment and prevention.
How similar studies have performed: Previous studies have defined roles of specific cells in skin health and repair, but this work offers a novel approach to visualize and manipulate cells in live models to understand complex interactions in genetically diverse skin.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Greco, Valentina — Yale University
- Study coordinator: Greco, Valentina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.