How skin cells control immune responses in inflamed skin
Keratinocyte-dependent regulation of innate immune responses in inflamed skin
This study looks at how skin cells help control the immune response during inflammation, especially in conditions like psoriasis and atopic dermatitis, to find new ways to improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11075905 on NIH RePORTER |
What this research studies
This research investigates how keratinocytes, the main cells in the outer layer of skin, regulate immune responses during inflammation. It focuses on understanding the signals these cells produce when stressed and how these signals affect the behavior of immune cells, particularly neutrophils, in conditions like psoriasis and atopic dermatitis. By examining the pathways involved in these processes, the research aims to uncover new insights into skin diseases and their treatment. Patients may benefit from a better understanding of their conditions and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic inflammatory skin conditions such as psoriasis, atopic dermatitis, and hidradenitis suppurativa.
Not a fit: Patients with acute skin injuries or non-inflammatory skin conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic inflammatory skin conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of keratinocytes in skin inflammation, suggesting that this approach could yield significant insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Coulombe, Pierre — University of Michigan at Ann Arbor
- Study coordinator: Coulombe, Pierre
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.