How skin bacteria may worsen food allergies in children with eczema
Mechanisms of enhanced food allergy by S. aureus skin colonization in Atopic Dermatitis
This study is looking at how certain bacteria on the skin might make food allergies worse in kids with eczema, and it hopes to find new ways to help prevent or treat those allergies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11042788 on NIH RePORTER |
What this research studies
This research investigates the link between skin colonization by Staphylococcus aureus and the exacerbation of food allergies in children with atopic dermatitis. The study focuses on understanding how the application of certain proteins and toxins from these bacteria can lead to increased allergic reactions when consuming specific foods. By examining the immune response and changes in intestinal permeability, the researchers aim to uncover the underlying mechanisms that contribute to severe food allergies. This could lead to new strategies for preventing or treating food allergies in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with atopic dermatitis who also have a history of food allergies.
Not a fit: Patients without atopic dermatitis or those who do not have food allergies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for food allergies in children with atopic dermatitis.
How similar studies have performed: Previous research has shown that similar approaches to understanding the immune response in allergic conditions have yielded significant insights, suggesting potential for success in this study.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Geha, Raif Salim — Boston Children's Hospital
- Study coordinator: Geha, Raif Salim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.